Office: 439-B Nicholson
Telephone: 2762-Office
E-mail:
RESEARCH INTERESTS
Aerosol transport in confined spaces: The transport and simultaneous interaction of aerosols with each other and the environment is a complex problem that has a wide scale of applications. My current work forcuses on computer code development to predict the spatial and temporal transport of poly-disperse systems. The code solves the Boltzmann transport equation at the hydrodynamic limit, and is validated using experimental benchmarks obtained in my aerosol lab at the LSU Nuclear Science Center. Applications include therapeutic delivery of medicine through the bronchial tract, and indoor dispersion of radioactive particles.
Radiation Biophysics: We are investigating the risk of heritable intragenic mutation with varying linear energy transfer (LET) radiation, and the effect of ultra-low LET radiation on the damage and repair of the DNA and the chromosome. We found that in the germline ultra low-LET radiation results in highly non-linear dose response, which cannot be explained by known quadratic effects observed in somatic cells. Our data suggest that DNA double-strand break is a necessary but not sufficient condition for chromosome break, and in addition to DNA repair mechanisms, there must exist a repair process that targets the multi-stranded histone or protamine structure.
CURRENT AND SELECTED PUBLICATIONS
- E. Sajo, "Evaluation of the exact coagulation kernel under simultaneous Brownian motion and gravitational setting," J. Aerosol Sci., submitted (2006).
- E. Sajo, W.R. Lee, "Dominant lethal mutations induced by low LET gamma radiation," PNAS, submitted (2006).
- E. Sajo and M.L. Williams, "TransMED: Deterministic Photon Transport for External Beam Therapy," in Software and Data Tools in Medical and Health Physics Radiation Transport Applications, edited by B. Kirk, ORNL, (2005). Published by Oak Ridge National Laboratory as a DOE Technical Report, ORNL/TM-2006/7, August, 2006.
- M.L. Williams, D. Ilas, E.Sajo, "Deterministic Photon Transport Calculations in General Geometry for External Beam Radiation Therapy Calculations," Medical Physics 30 (12), pp. 3183-3195 (2003).
- E. Sajo, "An Estimate of Spatial Uncertainty of Mean Concentrations Predicted by Gaussian Dispersion Models," Health Physics 85 (2), pp. 174-183 (2003).
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